Nitric Oxyde Concentration in Chronic Obstructive Pulmonary Disease Patients - SANOB Study
Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
- Among many other causes, Bronchial obstruction in Chronic Obstructive Pulmonary Disease
(COPD) is also caused by inflammation of peripheral airways walls.
- Neutrophils and other inflammatory mediators like Interleukin-6 (IL6), Interleukin-8
(IL8), Interleukin-1 alpha (IL-1 alpha),Interleukin-1beta (IL-1 beta), Tumor Necrosis
Factor alfa (TNF-alfa), Reactive Oxygen Species (ROS), Leukotriene B4 (LTB4), Nitric
Oxyde (NO) are implicated in the inflammation.
- NO is produced in response to physical and chemical stress on bronchial epithelium and
plays a critical role in small airways remodelling
- Exhaled NO concentration is usually used to monitor bronchial inflammation
- The relationship between stretch and strain of small airways and bronchial inflammation
is not well understood.
- The investigators hypothesis is that cyclic opening and closure of peripheral obstructed
airways through the consequent stretching and strain acting on them can provoke an
inflammatory response which can be monitored by exhaled NO.
- The pharmacological effects of bronchodilators may play a role on bronchial inflammation
by reducing the stretching stress on bronchiolar walls thus reducing the production of
NO in exhalate
- Data about these physiopathological aspects is missing in literature.
Phase:
Phase 4
Details
Lead Sponsor:
University of Milan
Collaborators:
Fondazione Salvatore Maugeri Università degli Studi di Ferrara