Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery

• Status: Unknown status
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether sodium nitrite administration 24 hours prior to or during coronary artery bypass surgery protects the heart better from lack of blood flow which occurs as part of this type of operation. The study will also determine what the mechanisms of this cardioprotection are.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Birmingham NHS Foundation Trust

Criteria

Inclusion Criteria:

• Patients undergoing elective first time multi-vessel coronary artery bypass surgery

• Older than 18 years of age

Exclusion Criteria:

• Significant psychiatric /neurological impairment that might prevent adherence to the requirements of the protocol or the ability to give informed consent

• Inability to read the Information Sheet.

• Redo operation

• Age >80 years

• Pregnancy

• Renal Impairment requiring pre-operative renal support

• Diabetes Mellitus

• Intended heart valve or additional surgery

• Episodes of angina or ischemia within 48hours prior to the procedure