Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
This 2-site randomized double blinded controlled trial is to confirm and more definitively
clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial
bioenergetics in older sedentary adults. This investigator will take an integrative
physiology approach to determine the effect of nitrite therapy on a comprehensive assessment
of mitochondrial energetics, skeletal muscle vascular function, and whole body physical
function (cardiorespiratory function, exercise endurance, strength, balance, and physical
activity) and fatigability.
Phase:
Phase 2
Details
Lead Sponsor:
Gladwin, Mark, MD
Collaborators:
National Institute on Aging (NIA) National Institutes of Health (NIH)