Nitro Oxide Inhalation Continued With Sildenafil on Neonatal Persistent Pulmonary Hypertension
Status:
Unknown status
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
Nitro Oxide (NO) inhalation was recognized as an effect treatment of Neonatal Persistent
Pulmonary Hypertension (PPHN), while the safety of NO long term application was under
investigation. Several research suggested too much NO2 was generated in the lung after long
term (> 72h) use of NO inhalation, which cause bad effects on PS production.
Sildenafil was proved to be effective to PPHN as NO. This medication has a similar clinical
effect but need monitoring of blood pressure. The possible hypotension effect restrict the
dosage of sildenafil, which limit the usage of sildenafil in severe PPHN. But we recommend
sildenafil to The purpose of the study was to establish if NO continued with sildenafil has
the same effect as single NO inhalation.