Nitroglycerin Skin Patches for Facilitating Cervical Ripening: A Randomized Controlled Trial

• Status: Completed
• Trial end date: 2017-09-21
• Target enrollment: 0
• Participant gender: Female

Summary

This study aims to establish the efficacy of transdermal glyceryl trinitrate as a nitric oxide donor in addition to dinoprostone for induction of cervical ripening in the third trimester through progression in the Bishop's score during 24 hour period.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams Maternity Hospital
• Collaborators: Dr. Ahmed S. Abd El-Hameed; Prof. Abdel-Megeeed I. Abdel- Megeeed
• Treatments: Dinoprostone; Nitroglycerin

Criteria

Inclusion Criteria:

1. Singleton living full-term fetus.

2. Cephalic presentation,

3. Bishop score less than 5,

4. Assuring fetal monitoring,

5. The mother does not have PROM,

Exclusion Criteria:

1. Expected fetal anomaly (eg. by ultrasound),

2. Abnormal presentation,

3. Multiple pregnancy,

4. Non assuring fetal CTG,

5. Fetus more than 90th percentile of expected weight,

6. Previous maternal obstructed labor or previous cesarean section,

7. Maternal obstetric or medical complication,

8. Structural anomaly of the uterus