Nitrous Oxide Added at the End of Sevoflurane Anesthesia and Recovery

• Status: Recruiting
• Trial end date: 2021-02-25
• Target enrollment: 0
• Participant gender: All

Summary

Addition of nitrous oxide N2O towards the end of prolonged isoflurane anesthesia hastens patients recovery. The hypothesis is that the addition of N2O at the end of prolonged sevoflurane anaesthesia also hastens early recovery without increasing the frequencies and intensity of PONV and improves quality of recovery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital Zadar
• Treatments: Anesthetics; Nitrous Oxide; Sevoflurane

Criteria

Inclusion Criteria:

• Adult patients, American Society of Anesthesiologists Physical status ASA PS I-III, scheduled for laparotomic and laparoscopic surgery expected to last 2 hours or more who can understand and signed informed consent.

Exclusion Criteria:

• Patients who will be discharged within 72 hours after surgery

• Patients on intensive care within few months before the study enrollment

• Diseases that impair gastric motility (diabetes mellitus, chronic cholecystitis, gastric and intestinal disease, neuromuscular disorders, neuropathies, liver dysfunction)

• Vestibular disease; history of migraine headaches, central nervous system injury

• Renal impairment

• Patients on antihistamines, antipsychotics, contraceptives, steroids within 72 hours before surgery

• Known hypersensitivity to drugs used in the study protocol

• Alcoholism, and/or opioid addiction

• Conditions that can influence the incidence of PONV, postoperative pain or morbidity (e.g., significant intraoperative surgery complications), intraoperative drug allergy, severe intraoperative hypotension, perioperative hypoxia, excessive blood loss, difficult intubation