No Operation After Short Course Radiotherapy Followed By Consolidation Chemotherapy In Locally Advanced Rectal Cancer
Status:
Recruiting
Trial end date:
2023-10-30
Target enrollment:
Participant gender:
Summary
This study is designed to explore the hypothesis that in patients with a Locally advanced
rectal cancer (LARC) treated with a Total neoadjuvant therapy (TNT) strategy based on short
course radiotherapy (5x5Gy) followed by neoadjuvant consolidation chemotherapy is associated
with a higher rate of pathological clinical response and sustained (>1year) complete clinical
response when compared to an historical cohort treated with long course chemoradiation
therapy (CRT), total mesorectal excision (TME) and adjuvant chemotherapy (ACT).