Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia

• Status: Recruiting
• Trial end date: 2023-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this double blind, randomised controlled non-inferiority trial is to compare the antinociceptive efficiency of an opioid-sparing and a conventional opioid-based anaesthesia protocol with the help of the CEcertificated Pain Monitoring Device (PMD-200).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Analgesics, Opioid

Criteria

Inclusion Criteria:

• Informed Consent as documented by signature

• Age older than 18 years

• Ability to give informed consent

• Undergoing scheduled general surgical, gynaecological or urological laparoscopic surgery

• American Society of Anesthesiology Score (ASA) status I, II, III

Exclusion Criteria:

• Inability to give informed consent

• ASA status IV and V

• Pregnant or breastfeeding women

• Allergy to one of the study drugs

• Urgent surgery

• Surgery with planned regional anaesthesia

• Outpatient surgery

• Atrioventricular block, intraventricular or sinoatrial block

• Atrial fibrillation

• Sinus bradycardia

• Cardiac insufficiency with a reduced left ventricular ejection fraction of below 40%

• Coronary artery disease

• Epilepsy

• Liver cirrhosis

• Chronic kidney disease (Clearance < 50ml/h)

• Chronic opioid therapy

• Chronic pain