Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)
Status:
Recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
The blood brain barrier (BBB) prevents some drugs from successfully reaching the target
tumor. Focused Ultrasound (FUS) using microbubbles and neuro-navigator-controlled sonication
is a non-invasive method of temporarily opening up the blood brain barrier to allow a greater
concentration of the drug to reach into the brain tumor. This may improve response and may
also reduce system side effects in the patient.
The primary purpose of this study is to evaluate the feasibility of safely opening the BBB in
children with progressive diffuse midline gliomas (DMG) treated with oral Panobinostat using
FUS with microbubbles and neuro-navigator-controlled sonication.
For the purpose of the study, the investigators will be opening up the BBB temporarily in
one, two, or three locations around the tumor using the non-invasive FUS technology, and
administrating oral Panobinostat in children with progressive DMG.