Non-Operative Management and Early Response Assessment in Rectal Cancer
Status:
Recruiting
Trial end date:
2025-07-31
Target enrollment:
Participant gender:
Summary
The investigators' data from a phase I study of short course radiation therapy followed by
chemotherapy showed 74% complete clinical response (cCR). Given the promising response rate,
the investigators are evaluating short course radiation therapy (SCRT) followed by
chemotherapy in a multi-institution phase II trial to validate the cCR rate of this treatment
paradigm. SCRT has not been prospectively evaluated in non-operative management for patients
with non-metastatic rectal adenocarcinoma.