Non-cancer Pain and Cognitive Impairment: A Disabling Relationship

• Status: Terminated
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity arthritis pain; and Describe the association of change in non-cancer pain self-report with an older adults functional status (BPI and WOMAC and brief physical performance measure) and to determine if cognitive status modifies this relationship.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chicago
• Treatments: Acetaminophen; Oxycodone

Criteria

Inclusion Criteria:

1. age over 65

2. Pain at least 3 months duration

3. Pain greater in lower extremity than other anatomical site with ambulation

4. Pain self-report of moderate intensity of higher on an average day

5. Community-dwelling

6. Ambulatory

7. Physician states participants have decision-making capacity to enroll into the trial

8. Participants with cognitive impairment have a reliable caregiver

9. Inadequate pain relief from NSAIDS and/or acetaminophen in the past

Exclusion Criteria:

1. Current cancer requiring chemotherapy

2. History of addiction to opioids or other controlled substance

3. Consumes more than 2 alcoholic drinks a day

4. Severe balance disturbance

5. Intra-articular steroid injection in the past 6 weeks