Non-invasive Ventilation vs. Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Acute asthma produces greatly increased work of breathing and increased oxygen requirement
secondary to bronchial narrowing and airway obstruction by inflammatory secretions. There is
growing evidence that non-invasive ventilation can reverse these processes more efficiently
than conventional asthma therapy. Surprisingly, there have not yet been any large scale
prospective controlled studies to investigate this hypothesis, (either in adults or
children). Consequently, the aim of this study is to determine if the use of non-invasive
positive airway pressure, for children admitted to hospital with an acute exacerbation of
asthma, reduces their work of breathing, need for adjunctive medications, and shortens the
length of hospital stay, compared to current standard therapy.
Phase:
N/A
Details
Lead Sponsor:
University of British Columbia
Collaborator:
Post Graduate Institute of Medical Education and Research, Chandigarh