Non-malarial Febrile Illness in Children in Areas of Perennial Malaria Transmission

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the causes of non-malarial febrile illness in children living in an area of perennial malaria transmission and to determine if these children who test negative for malaria by rapid diagnostic test receive any benefit from antimalarial therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centers for Disease Control and Prevention
• Treatments: Artemether; Artemether-lumefantrine combination; Artemether, Lumefantrine Drug Combination; Artemisinins; Lumefantrine

Criteria

Inclusion Criteria:

• Age 6 to 59 months.

• Present to health facility with fever (oral or rectal temperature ≥38°C or axillary temperature ≥37.5°C) or history of fever in the past 48 hours.

• Have negative rapid diagnostic test for malaria.

• Live within the boundaries of the officially recognized catchment area of Miono Health Center (within approximately 10 km of the health facility).

Exclusion Criteria:

• Plan to travel or leave the area within the next 3 months.

• Have been treated for malaria in the 2 weeks prior to enrollment.

• Have clinical evidence or history of danger signs: convulsions, lethargy, loss of consciousness, unable to eat or drink, vomiting everything.

• Have severe, life-threatening anemia: hemoglobin ≤5g/ dL.

• Have very low weight for age, severe pneumonia, or very severe disease as defined in the Integrated Management of Childhood Illness algorithms.

• Have a history of sensitivity to artemisinin derivatives or Artemether-Lumefantrine.

• Have previously been enrolled in this study or another ongoing cohort study of malaria treatment options at these health facilities

• Chronic disease requiring ongoing medical care (i.e HIV on cotrimoxazole).