Non-operative Treatment of Acute Non-perforated Appendicitis

• Status: Completed
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Gold Standard treatment of appendicitis is appendectomy but non-operative treatment of non-perforated appendicitis with antibiotics is also under trial. Although appendectomy is curative but it is an invasive procedure done under general anesthesia with different risks and complications during and after operation, leading to disturbance of child daily routines and activities. Reported rates of perioperative complications are from 5% - 10%, with serious complications occurring in 1% to 7% of patients.

Children presenting with acute (<2 days) right iliac fossa pain with pediatric appendicitis score >7, with none of the following on ultrasonography: abscess formation, or loss of the echogenic sub-mucosal layer of the appendix or presence of an appendicolith or periappendiceal fluid collection will be labeled as having appendicitis.

After diagnosis we divided the patients into two groups.patients in group A will be treated with antibiotics and appendectomy is done for group B patients.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: King Edward Medical University
• Treatments: Meropenem; Metronidazole

Criteria

Inclusion Criteria:

• All children between 5 and 15 years of age of both genders admitted in the pediatric surgery emergency with having PAS score >7will be included in the study.

Exclusion Criteria:

• Patient with suspicion of perforated appendicitis on the basis of generalized peritonitis and abscess formation on ultrasound.

• Patients with an appendicular mass, diagnosed by clinical examination and ultrasonography.

• Patient with previous non-operative treatment of acute appendicitis (recurrent appendicitis)

• Patients with C-reactive proteins > 40 mg/L.

• Patients with history of any previous abdominal surgery.