In this randomized observer-blinded trial the analgesic efficacy of intravenous esmolol, as
alternative to intraoperative opioids, is tested in patients undergoing laparoscopic
prostatectomy and upper gastrointestinal surgery (such as Nissen fundoplication). The purpose
of this study is to determine whether intravenous esmolol improves postoperative analgesia
and accelerate the surgical recovery. We hypothesize that patients receiving intravenous
esmolol will consume less analgesic in the postoperative period, will have less
opioid-related side effects and will recover their functional status faster then patients
receiving intravenous esmolol.
Patients will be stratified according to the type of surgical procedure in 2 arms: 40
patients with prostate cancer and undergoing elective laparoscopic prostatectomy, and 40
patients with gastro-esophageal reflux undergoing upper gastrointestinal surgery (Nissen
funduplication) will be enrolled.
Patients will receive total intravenous anesthesia with propofol and esmolol (Esmolol group,
n=20 in each arm) or propofol and remifentanil (Remifentanil Group, n=20 in each arm).
Phase:
N/A
Details
Lead Sponsor:
McGill University Health Center McGill University Health Centre/Research Institute of the McGill University Health Centre