Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.

• Status: Terminated
• Trial end date: 2016-01-16
• Target enrollment: 0
• Participant gender: All

Summary

The combination of different analgesic drugs and/or analgesia techniques is part of the standard management of postoperative analgesia. The analysis of the literature reveals a lack of comparison of the associations of non-opioid analgesic (NOA) with morphine for postoperative analgesia.

The objectives of this study are :

• comparing the morphine sparing effect of different combination of 3 NOA (paracetamol, nefopam, ketoprofen) for postoperative analgesia.

• determining whether the morphine-sparing effect is associated with or without a reduction in the incidence of morphine side effects.

• evaluating the effects of NOA on postoperative hyperalgesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rennes University Hospital
• Treatments: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Ketoprofen; Morphine; Nefopam

Criteria

Inclusion Criteria:

• Adults older than 18 years

• Receiving scheduled surgery requiring the use of a PCA to treat postoperative pain

• Patients with a written informed consent

• Patients with a written informed consent for the sub-study on hyperalgesia (patients in the centers concerned)

• Affiliate to a social security system

Exclusion Criteria:

• Allergy to morphine, paracetamol, nefopam or ketoprofen or to any of their excipients

• Absorption of morphine and / or NOA within 24 hours before surgery

• Absorption of methadone within 48 hours before surgery

• History of epilepsy

• Renal insufficiency (creatinin clearance <30 ml / min MDRD)

• Hepatic insufficiency

• Severe respiratory insufficiency

• Pregnancy or breastfeeding women

• History of seizures

• Symptomatic urethroprostatic disorders

• Angle-closure glaucoma

• Gastrointestinal, cerebrovascular or other evolving bleedings

• Active peptic ulcer or active gastritis

• Severe heart failure

• History of asthma triggered by taking ketoprofen or similar substances

• Disable adult person under guardianship

• Use of nitrous oxide during anesthesia protocol