Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis

• Status: Recruiting
• Trial end date: 2025-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to examine if the use of antioxidant supplements impacts exercise intolerance in people with CF.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Virginia Commonwealth University
• Treatments: Resveratrol

Criteria

Inclusion Criteria:

CF

• Diagnosis of CF

• Men and women (> 18 yrs. old)

• FEV1 percent predicted > 40%

• Patients with or without CF related diabetes

• Resting oxygen saturation (room air) >90%

• Traditional CF-antioxidant medications

• Ability to perform reliable/reproducible PFTs

• Clinically stable for 4 weeks (no exacerbations or need for antibiotic antioxidant within 4 weeks of testing or major change in medical status)

• Pancreatic sufficient and pancreatic insufficient patients

Exclusion Criteria:

CF

• Children 17 years old and younger

• FEV1<40% predicted

• Resting O2 saturation <90%

• Clinical diagnosis of heart disease

• Clinical diagnosis of PAH

• Febrile illness within 4 weeks of a study visit

• Antioxidant for pulmonary exacerbation within 4 weeks of a study visit

• Currently smoking, pregnant or nursing

• Vasoactive medications (i.e. nitrates, beta-blockers, Viagra etc.)

• Patients with B. Cepacia