Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis

• Status: Unknown status
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The Purpose of this study is to assess the correlation between the inflammatory periodontal status and the medical treatment status in Polycystic Ovary Syndrome(PCOS) women with systemic inflammation and to evaluate the effect of non-surgical periodontal therapy in the form of scaling and root planing along with medical treatment on the level of serological marker of inflammation (High sensitivity-C Reactive Protein) and insulin resistance in PCOS women with chronic periodontitis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Postgraduate Institute of Dental Sciences Rohtak
• Treatments: Inositol

Criteria

Inclusion Criteria:

• Females of reproductive age group (15-35 yrs)

• Subjects diagnosed with PCOS according to AES (Androgen Excess Society)/2006 criteria:

• Presence of hyperandrogenism (clinical and/or biochemical)

• Oligo or anovulation

• PCOM (Polycystic ovarian morphology)- at least one ovary with 1)12 or more follicles (2-9 mm in diameter) or 2) Ovarian volume >10 ml

• Presence of ≥20 natural teeth

• Patients having Chronic Periodontitis will be defined according to division of Oral Health at the Centers for Disease Control and Prevention (CDC) in collaboration with American Academy of Periodontology (AAP) Moderate periodontitis: ≥ 2 interproximal sites with AL, ≥4 mm (not on same tooth), or ≥2 interproximal sites with PD ≥5 mm (not on same tooth) (Page and Eke 2007)

Exclusion Criteria:

Any history of thyroid dysfunction, hyperprolactinemia, androgen -secreting tumour, nephrotic syndrome, chronic renal failure.

• Significant cardiovascular disease.

• Established type 1 or type 2 diabetes mellitus.

• Active cancer within the last past 5 yrs.

• Smokers and alcoholic subjects.

• History of systemic antibiotics or oral contraceptives usage within last 3 months.

• Periodontal treatment within 6 months prior to study