Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens

• Status: Terminated
• Trial end date: 2020-02-19
• Target enrollment: 0
• Participant gender: All

Summary

To demonstrate noninferiority of three different empiric antimicrobial regimens compared to the traditional antimicrobial regimen for the management of grade III open fractures as well as evaluate outcomes among these groups.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mercy Health Ohio
• Treatments: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Cefazolin; Ceftriaxone; Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Gentamicins; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sulbactam; Sultamicillin; Tazobactam

Criteria

Inclusion Criteria:

• Age great than/equal to 18 years

• Diagnosis of Grade III open fracture

Exclusion Criteria:

• Water-borne injury

• Farm-related injury