Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation

• Phase: Phase 3

Details

• Lead Sponsor: Baqiyatallah Medical Sciences University

Criteria

Inclusion Criteria:

• a history of previous exposure to sulfur mustard

• worsening dyspnea during the last 10 days

• respiratory rate >25/min

• arterial pH<7.35

• PaCO2 of >50 mmHg

• PaO2 of <50 mmHg

Exclusion Criteria:

• recent pneumothorax (<1 month)

• severe respiratory failure or hemodynamic instability with forthcoming intubation

• FIO2 of <0.4

• impaired consciousness or absence of patient cooperation

• facial lesions precluding NIV