Noradrenaline, Acetylcholine and Dynamic Learning in Healthy Humans
Status:
Completed
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to characterize the role of central norepinephrine and acetylcholine
on reward and emotion related information processing in healthy volunteers using behavioural
tasks and pupillometry (with eye tracking equipment). The pharmacological compounds used in
the study (reboxetine and rivastigmine) are used as tools to manipulate these systems rather
than to treat patients. The aim of the study is not to study the clinical effects,
pharmacodynamics, adverse reactions, absorption, distribution, metabolism or excretion of the
drugs. Further, the population studied is non-clinical, the drugs are not administered in a
therapeutic dosing regimen (only a single dose of study drug will be administered) and the
investigators do not measure clinically significant outcomes.