Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty

• Status: Recruiting
• Trial end date: 2023-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical structures. Despite that advantage, after its deflation, there is a blood volume shift towards that ischemic area, which may decrease cardiac preload leading to hypotension

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Norepinephrine; Terlipressin; Vasopressins

Criteria

Inclusion Criteria:

• Adult Patients of both gender

• American Society of Anesthesiologists (ASA) I or II

• scheduled for elective unilateral total knee arthroplasty

Exclusion Criteria

• Patient refusal.

• Major cardiopulmonary disorders

• Uncontrolled systemic hypertension.

• Hepatic or renal disorders.

• Patient with relative contraindication for tourniquet use as peripheral vascular disease, sickle cell anemia, deep venous thrombosis, diabetic neuropathy and crushed injury.

• Cases having American Society of Anesthesiologists [ASA] > II

• Coagulopathy and bleeding tendency.

• Revision knee arthroplasty and bilateral knee arthroplasty