Norepinephrine for Hypotension in Cesarean Section

• Status: Not yet recruiting
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Hypotension is a very common consequence of the sympathetic vasomotor block caused by spinal anesthesia for cesarean section. Maternal symptoms such as nausea, vomiting and dyspnea frequently accompany severe hypotension, and adverse effects on the fetus, including depressed APGAR scores and umbilical acidosis, have been correlated with severity and duration of hypotension. Because hypotension is frequent, vasopressors should be used routinely and preferably prophylactically.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Norepinephrine; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• Patients who fall in category 2 and 3 according to the classification of Caesarean section made by Royal College of Obstetrician and Gynaecologists.

Exclusion Criteria:

• Patient refusal either to study enrollment or to spinal anesthesia.

• Any absolute contraindication to spinal anesthesia e.g. coagulopathy, skin infection at site of injection.

• Allergy to any of study drugs.

• Patients with cardiac morbidities, hypertensive disorders or peripartum bleeding

• BMI > 40 kg/m²

• Baseline systolic blood pressure < 100 mmHg.