Norepinephrine or Phenylephrine in Bolus for Hypotension in Cesarean Delivery

• Status: Completed
• Trial end date: 2020-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study evaluate the ability of phenylephrine and of noradrenaline to maintain normal systemic arterial blood pressure and heart rate in healthy pregnant women submitted to cesarean section with spinal anesthesia. Half of participants will receive bolus of phenylephrine while the other half will receive bolus of noradrenaline.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital dos Servidores do Estado do Rio de Janeiro
• Treatments: Norepinephrine; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• Pregnant women, with single gestation, with cesarean programming to be performed under spinal anesthesia;

• Age above 18 years;

• Physical State American Society of Anesthesiologists (ASA) II and III;

• Weight between 50kg and 120kg;

• Height between 140cm and 180cm.

Exclusion Criteria:

• Refusal to participate in the study;

• Pregnant women with fetus with known abnormalities;

• Pregnant women with cardiovascular disease;

• Pregnant women with pregnancy-specific hypertensive disease;

• Allergy to any medication to be used in the study;

• Users of monoamine oxidase inhibitors;

• Users of tricyclic antidepressants;

• Emergency caesarean section due to acute fetal distress;

• Situations in which the sensory level after single intrathecal injection of the local anesthetic does not reach at least T6 within 5 minutes after spinal anesthesia.