Normobaric Hyperoxygenation for Prevention of Contrast Induced Nephropathy
Status:
Unknown status
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Acute renal failure induced by radiographic contrast agents is a known complication of
coronary angiography.hypoxia plays a major role in the pathogenesis of Contrast induced
nephropathy.
The aim of the current study is to investigate the effect of normobaric hyperoxygenation
therapy on renal functions in patients at high risk for CIN undergoing coronary angiography.
The study is aimed to include 180 consecutive patients with estimated GFR base on the MDRD
equation of less than 60 mL/min/1.73 m2 that are candidates for elective coronary
angiography. Patients with acute renal failure, acute myocardial infarction, noncompensated
congestive heart failure, hemodynamic instability, known sensitivity to contrast media and
patients who had been exposed to contrast media during the last 3 months will be excluded.
Patients with oxygen blood saturation of less than 94% at room air will also be excluded from
the study.
Study protocol Patients will be randomly assigned to receive either 100% oxygen by mask
(treated group) or breath room air (control group) for duration of 4 hours starting at the
beginning of the angiographic procedure.
All patients will be treated with 0.9% salin and NAC. Coronary angiography will be performed
using nonionic, low osmolar iodine (Ultravist®-370) (Schering, Berlin, Germany).
All patients will be hospitalized 1 day before and at least 24 hours following angiography.
Blood samples for urea, creatinine and cystatin- C will be drawn on admission, 6, 24 and 48
hours after coronary angiography. Urine sample will be taken 24 hours before angiography and
6, 24 and 48 hours post angiography. In those urine samples the ratio between creatinine to
Isoprostanes and NO will be evaluated.