Normothermia in Patients With Acute Cerebral Damage

• Status: Unknown status
• Trial end date: 2009-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of our study is to verify wherever normothermia (achieved with diclofenac administration) may improve intracranial pressure control and may limit secondary cerebral damage thus positively influencing outcome in patients with acute cerebral damage admitted to ICU.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
• Treatments: Diclofenac

Criteria

Inclusion Criteria:

• Patients with severe traumatic injury or subarachnoid hemorrhage in coma (GCS<8), intubated, mechanically ventilated with intracranial pressure (ICP) and invasive arterial pressure monitoring

Exclusion Criteria:

• Know adverse reactions with NSAI

• Platelets count < 20,000/dl

• Gastric or duodenal ulceration in active phase

• Hepatic insufficiency, cirrhosis or previous liver transplant

• Acute or chronic renal insufficiency

• Coronary insufficiency, acute myocardial infarct in the previous 6 month

• Barbiturate coma

• Patients in therapy with acetylsalicylic acid, lithium, digoxin, methotrexate and cyclosporin.

• Known or suspected pregnancy