Normothermic Ex Vivo Lung Perfusion (EVLP) For An Improved Assessment of Donor Lungs For Transplantation

• Status: Completed
• Trial end date: 2010-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The use of ex vivo lung perfusion (EVLP) will allow for a secondary evaluation technique for donor lungs that fail to meet standard acceptability criteria. This advanced assessment might lead to increased utilization rates of donor lungs and improved outcomes after lung transplantation.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: XVIVO Perfusion
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria for donor lung:

1. Recipient to undergo a single or bilateral Lung Transplantation

2. Last donor PaO2/FiO2 ≤ 300mmHg

3. Poor oxygenation and/or poor lung compliance is the primary reason for unsuitability

4. Absence of pneumonia, persistent purulent secretion on bronchoscopy or significant mechanical trauma

Exclusion Criteria:

1. Infection

2. Aspiration

3. Significant mechanical lung injury - contusion

4. Infectious diseases : HIV, Hepatitis B and C, HTLV & Syphilis

5. Malignancy