Normoxemic Versus Hyperoxemic Extracorporeal Oxygenation in Patients Supported by Veino-arterial ECMO for Cardiogenic Shock

• Status: Not yet recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Because of dual oxygenation and oxygenator performance (PO2 postoxygenator up to 500 mmHg), hyperoxemia (PaO2 > 150 mmHg) is frequent in veino-arterial ECMO, especially in the lower part of the body, which is mainly oxygenated by ECMO.

By enhancing oxygen free radicals' production, hyperoxemia might favor gut, kidney and liver dysfunction.

We hypothesize that targeting an extracorporeal normoxemia (i.e. PO2 postoxygenator between 100 and 150 mmHg) will decrease gut, kidney and liver dysfunctions, compared to a liberal extracorporeal oxygenation.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Criteria

Inclusion Criteria:

• Patient supported by veino-arterial ECMO for cardiogenic shock for less than 6 hours

• Affiliation to social protection

Exclusion Criteria:

• Age < 18 ans

• Pregnancy

• Opposition of the patient or his relatives

• Cannulation during cardiopulmonary resuscitation

• Cardiopulmonary resuscitation duration > 10 minutes before ECMO implantation

• Patient moribound on the day of randomization

• Chronic hemodialysis

• Chronic intestinal disease