Novel MRI Techniques for the Characterization and Treatment Assessment of High Grade Brain Lesions

• Status: Recruiting
• Trial end date: 2020-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This trial studies different magnetic resonance imaging (MRI) techniques and their ability to provide clearer pictures of lesions in patients with high grade brain lesions. An MRI is a type of imaging scan. Using different MRI techniques to produce clearer images of the brain may help researchers learn about the features of brain lesions and the effects of chemotherapy and/or radiation therapy.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: M.D. Anderson Cancer Center
• Collaborator: National Cancer Institute (NCI)

Criteria

Inclusion Criteria:

• At least one enhancing lesion, aggregate of enhancing foci, and nonenhancing lesion measuring at least 1 cm in size and is suspected to be a high grade brain neoplasm

• Patient is dispositioned to surgery, chemotherapy and/or radiation therapy

• Patient is able to understand and give own consent to participate in the study

Exclusion Criteria:

• Contraindication to magnetic resonance imaging (MRI) as assessed by the investigator's standard of care magnetic resonance (MR) screening procedure, which includes implants or devices that are unsafe in the magnetic environment

• Contraindication or history of allergy to Gadolinium-based (gadobutrol [Gadovist], gadobenate dimeglumine (Multihance]) intravenous contrast

• Verbal confirmation of pregnancy or a positive pregnancy test result in patient record

• Prior partial (greater than 50%) or gross total resection of primary tumor

• Prior chemotherapy or radiation treatment to brain