There are no guidelines for appropriate nutritional management of weight loss or wasting in
HIV infection. Some treatments may increase weight, but without improving muscle mass or
quality of life. In this clinical trial AIDS patients with wasting are randomized to one of
three nutritional strategies and studied over a 12-week period: 1) optimal oral nutrition
with counseling and protein and calorie supplementation, and a placebo pill; 2) optimal oral
nutrition with the oral androgen, oxandrolone at 20 mg daily; and 3) optimal oral nutrition
with progressive resistance training (PRT). In all participants, dietary intervention is
maximized by weekly personalized counseling to address individual issues and concerns. Two
primary outcomes are assessed: thigh muscle mass and quality of life. Our findings can be
used to develop guidelines for standards of nutritional care among AIDS patient with the
wasting syndrome.
Phase:
Phase 4
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)