Nutrition Supplementation in Hospitalized Patients

• Status: Completed
• Trial end date: 2018-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with severe malnutrition risk are 7.4 times more likely to die in hospital than well-nourished patients, and carry a 30-day readmission rate of >46%. Although malnutrition is common and is associated with extremely poor outcomes, it is neglected and undertreated. This is a randomized controlled pilot trial to rapidly identify at-risk hospitalized medical patients, and then provide nutritional supplementation in hospital and after discharge for 28 days. In select at-risk patients, 5 days of nutrition delivered through a peripheral vein will be used in addition to oral nutritional supplementation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lawson Health Research Institute
• Collaborator: Academic Medical Organization of Southwestern Ontario
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Subjective Global Assessment (SGA) category B or C.

• Have been hospitalized for less than 48 hours.

Exclusion Criteria:

• Have an allergy or intolerance to any component of the oral supplement or parenteral nutrition.

• Have a contraindication to administration of IV fluid (i.e. are in volume overloaded state, are being given IV furosemide).

• Are currently suffering from refeeding syndrome.

• Have a pre-existing medical condition that prevents oral intake of full fluids.

• Have a diagnosis or suspicion of septic shock.

• Have an expected length of stay of less than 48 hours from the time of assessment.

• Have a current diagnosis of diabetic ketoacidosis or hyperglycemic hyperosmolar syndrome.