NuvaRing Versus Marvelon in the Coordination of In Vitro Fertilization Cycles
Status:
Terminated
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
Presently, a long protocol in an In Vitro Fertilization (IVF) cycle, patients need to take
Marvelon, a drug that inhibits the follicular development at the beginning of the cycle in
order to better control and also plan the onset of the ovary stimulation with gonadotropin.
Marvelon is taken daily as soon as menstruation starts for a period of 14 to 21 days.
Ideally, it has to be taken at the same time everyday and not be forgotten. This may cause
higher stress level for some users. Presently on the market, there is a ring-shaped
contraceptive device inserted in the vagina at day 1 of the cycle called NuvaRing. The
purpose of this device is similar to an oral contraceptive. However, the benefit of NuvaRing
is that it can be left in place for a period of up to 35 days without any other manipulation
and keep an adequate rate of hormone for contraception. Moreover, NuvaRing shows better
hormone stability in the blood. Although the side effects and the benefits are comparable for
the two treatments, some studies have shown that more patients would respect the treatment
with NuvaRing and that the level of satisfaction would be higher in women using NuvaRing when
contraception is needed.
The purpose of the study is to compare the rate of satisfaction as well as the level of
stress in women using Marvelon daily or NuvaRing with single insertion in a long protocol.
Moreover, this study allow us to verify if using NuvaRing, a vaginal contraceptive releasing
constant daily doses for up to 35 days will allow us to facilitate the planning of In Vitro
Fertilization cycles in long protocol.