O2 Transport and Utilization in Health and Lung Disease

• Status: Not yet recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood. Therefore, the focus of this study is on the role of a deficit in tetrahydrobiopterin and nitric oxide synthase uncoupling induced by chronic oxidative stress on metabolic and vascular abnormalities in skeletal muscle of patients suffering from COPD.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Massachusetts, Amherst

Criteria

Inclusion Criteria:

• All subjects must be between the age of 18 and 85 years;

• For the COPD cohort, patients with a diagnosis of stable COPD (i.e., those not experiencing an acute exacerbation of symptoms) and spirometric evidence of airway obstruction (FEV1 <80% predicted, FEV/FVC<0.70);

• Ability to perform motor tests;

• Ability to provide informed consent

Exclusion Criteria:

• uncontrolled hypertension;

• hyperlipidemia;

• recent exacerbation;

• Major cardiovascular event procedure (<3 months);

• Pregnancy

• known significant hepatic, renal disease, active substance abuse

• contraindication to MRI, claustrophobia