O2 Transport and Utilization in Health and Lung Disease
Status:
Not yet recruiting
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of
Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood. Therefore,
the focus of this study is on the role of a deficit in tetrahydrobiopterin and nitric oxide
synthase uncoupling induced by chronic oxidative stress on metabolic and vascular
abnormalities in skeletal muscle of patients suffering from COPD.