O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
This phase II trial is studying how well giving O6-benzylguanine together with temozolomide
works in treating young patients with recurrent or progressive gliomas or brain stem tumors.
Drugs used in chemotherapy, such as O6-benzylguanine and temozolomide , work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. O6-benzylguanine may help temozolomide work better by making tumor cells more
sensitive to the drug. Giving more than one drug (combination chemotherapy) may kill more
tumor cells.