OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial
Status:
Recruiting
Trial end date:
2022-09-30
Target enrollment:
Participant gender:
Summary
OPTIMAS is a large, prospective, partially blinded randomised controlled trial of early
(within ≤4 days [96hrs]) or standard (between day 7 and day 14 after stroke onset) initiation
of anticoagulation after stroke in patients with atrial fibrillation (AF), using any licensed
dose of a direct oral anticoagulant (DOAC). The trial will use a non-inferiority gatekeeper
approach to test for non-inferiority of early anticoagulation followed by a test for
superiority, if non-inferiority is established.