Objective Diagnostic Markers and Personalized Intervention in MDD Patients
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Major depressive disorder (MDD) is one of the most common psychiatric disorders, with high
recurrence rate, suicide rate and disability rate. It's reported that the global burden
caused by MDD will be up to the second rank among all the disease burdens by 2020. China is
also confronted with the daunting challenges against MDD. It's assessed that the monthly
incidence of MDD is 6.1%, non-hospitalizing rate reaches up to 92% and the non-treatment rate
is approximate 95%. However, to date, the pathogenesis of MDD is obscure and the current
therapies don't work well. Therefore, it's urgent and critical to elucidate the pathogenesis
of MDD, to develop early diagnostic criteria and effective intervention in MDD. Considering
the diversity of weights on genetic factor and environmental factor in MDD, in this project,
the investigators aim firstly to explore the effect of "genetic-environmental interaction"on
the pathogeny of MDD for classifying MDD into "genetic type", "environmental type" and
"others" based on a case-control study. We next conduct the neurobiological, neurocognitive
and psycho-behavioral assessments among MDD, schizophrenia and healthy groups to screen the
salient endophenotypes for establishing the diagnostic models of MDD . The investigators
further analyse the changes of these indicators after 8 weeks'medication to select the
potential predictors for therapeutic evaluations and interventional options in MDD patients.
Finally, the investigators continue a 2-year follow-up study to test and verify the
predictors of prognosis in MDD patients.
Phase:
N/A
Details
Lead Sponsor:
Peking University
Collaborators:
Capital Medical University Dalian Seventh People's Hospital First Hospital of China Medical University Peking Union Medical College Hospital The First Affiliated Hospital of Shanxi Medical University The First Hospital of Hebei Medical University Tianjin Anding Hospital Tianjin Medical University General Hospital