Observation and Treatment of Pulmonary Microthrombosis in Childhood Pneumonia With Elevated D-dimer
Status:
Completed
Trial end date:
2018-02-01
Target enrollment:
Participant gender:
Summary
Objective
1. Master the clinical feathers, imaging features and laboratory diagnosis characteristics
and economic costs of children pneumonia with higher D-dimer:
1. Compare the characteristics of different groups of children in the course of the
disease，clinicalsymptoms and signs;
2. All the children in the study need to do enhanced CT, to observe if there were
intrapulmonary vascular thrombosis and necrosis pneumonia signs;
3. compared changes of coagulation index beside D-dimer.
2. Compared with low molecular weight heparin prevention Disseminated intravascular
coagulation（DIC） dose and instructions to the recommended dose in safety and
effectiveness,and proposed elevated anticoagulation D-Dimer specification of the clinical
treatment of children with pneumonia.
Background and rationale:
Pneumonia is the main cause of lung function injury and death in children. The high blood
coagulation state can lead to the formation of pulmonary vascular thrombosis, local pulmonary
ischemia and necrosis, which may be an important mechanism for the occurrence of necrotizing
pneumonia and pulmonary embolism in children with pneumonia. Elevated D-dimer is an important
predictor of pulmonary thrombosis and necrotizing pneumonia. At present, D-Dimer in many
children with severe pneumonia is found to increase, the symptom is severe, the late stage of
the performance of necrotizing pneumonia, seriously affect the children's lung function and
quality of life.