Observation of Propofol Titration at Different Speeds

• Status: Not yet recruiting
• Trial end date: 2021-02-14
• Target enrollment: 0
• Participant gender: All

Summary

Propofol is one of the most widely used anesthetics for its fast onset and quick elimination. The conventional speed of its induction dose often causes severe hemodynamics fluctuations with hypotension and arrhythmia. The recommended dosage on the drug insert comes from group pharmacokinetic studies which does not apply to the specific situation of every patient, so the investigators emphasize individualized medication. The investigators have observed the titration of propofol in general anesthesia induction, and found that the dosage was less and the hemodynamics was becoming more stable. At the same time, the investigators found that the hemodynamics still has obvious fluctuations in the titration of the administration rate recommended in the instructions. The investigators intend to further compare the effects of propofol titration administration at different rates for hemodynamics and stress during the induction period of general anesthesia, and find a safer and more appropriate rate of administration.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: SanQing Jin
• Treatments: Remifentanil; Rocuronium

Criteria

Inclusion Criteria:

1. Age 18-60 Years old

2. Elective surgery for general anesthesia through oral tracheal intubation and surgery is expected to last more than 2 hours

3. The American Society of Anesthesiologists(ASA) grade is I or II, and the cardiac function is 1-2;

4. Body mass index (BMI) 18-30 kg/m2;

Exclusion Criteria:

1. Patients have severe heart, lung, liver, and kidney diseases (heart function grade>3 / respiratory failure / liver failure / renal failure)

2. Patients with arrhythmia: sinus bradycardia (ventricular rate <60 beats/min), atrial fibrillation, atrial flutter, atrioventricular block, frequent ventricular premature, multi-source ventricular premature, ventricular premature R on T, Ventricular fibrillation and ventricular flutter.

3. Patients who are expected to be difficult to intubate, hypoalbuminemia(albumin is less than 35g/L), hypertension and diabetes;

4. Patients with a higher risk of reflux and aspiration, such as full stomach, gastrointestinal obstruction, gastroparesis, and pregnant women;

5. Patients have schizophrenia, epilepsy, Parkinson's disease, intellectual disability, hearing impairment, abnormal EEG, etc.;

6. Patients who take sedative and analgesic drugs for a long time;

7. Patients who are allergic to propofol or its fat emulsion;

8. Patients who are participating in other clinical trials, and who refuse to sign informed consent.