Ocular Changes After Ivermectin - (DOLF IVM/Oncho)

• Status: Completed
• Trial end date: 2019-08-23
• Target enrollment: 0
• Participant gender: All

Summary

The DOLF Ocular Changes after Ivermectin study will investigate the kinetics of O. volvulus microfilaria (Mf) in the eye following treatment with ivermectin. The primary objective is to determine the proportion of participants with complete Mf clearance from the eye at 3 and 6 months following treatment with ivermectin (IVM).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborators: Case Western Reserve University; University of Health and Allied Sciences
• Treatments: Ivermectin

Criteria

Inclusion Criteria:

• Have at least 1 palpable subcutaneous nodule (onchocercoma) and ≥ 1 Mf/mg of skin (by skin snip)

Exclusion Criteria:

• Pregnancy and breastfeeding mothers within 1 month of giving birth

• Have base line eye diseases including glaucoma, uveitis, severe keratitis, and/or cataracts that interfere with visualization of the posterior segment of the eye.

• Prior allergic / hypersensitivity reactions or intolerance to ivermectin

• Treatment with ivermectin in the past 6 (six) months