Oestradiol Supplementation in Luteal Long Agonist Fresh In Vitro Fertilization/Intra Cytoplasmic Sperm Injection ( IVF/ICSI) Cycle .

• Status: Unknown status
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

Whether oestradiol administration affects the pregnancy rate in long agonist fresh IVF/ICSI cycles. Oestradiol level will be measured the day of HCG trigger to assess whether oestradiol level affects cycle outcome results.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Polyestradiol phosphate; Progesterone

Criteria

Inclusion criteria:

1. Age group 20-38 years old.

2. Patients Undergoing gonadotropin Releasing Hormone (Gn RH) long agonist protocol, with fresh embryo transfer.

3. Day 3 Grade 1 embryos.

4. Trilamellar endometrium with ranging endometrial thickness from 8 mm to 14 mm.

Exclusion criteria:

1. Karyotypic abnormalities in either partner.

2. Patients with uterine abnormalities.

3. G3-G4 quality embryos.

4. Estradiol level 10,000 or more at time of trigger.

5. Cases of egg donation/sperm donation/embryo donation.

6. Polycystic ovary syndrome (PCOS )patients.

7. Poor responders (maternal age >40, Antral follicle counts (AFC )<5, Anti Mullerian Hormone (AMH )<1 and previous trial <5 oocyte retrieved ) (bologna criteria 2011)

8. Those with 3 or more implantation failure.

9. Endometrial thickness <8 or >14mm.

10. Severe male factor.