Ofloxacin Concentration-toxicity Relationship in the Elderly
Status:
Recruiting
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
Ofloxacin is a gold standard antibiotic for the treatment of bone and joint infections due to
sensible staphylococcus strains. However, in the elderly, inter-individual variability of the
pharmacokinetics may reduce the efficacy or increase toxicity. The occurrence of ofloxacin
side effects is likely to be increased in case of higher exposition. However, the serum
concentration-toxicity relationship has not yet been determined. The purpose of this project
is to assess the association between the residual serum concentration of ofloxacin at day 3
and the occurrence of at least one adverse effect attributable to ofloxacin, and determine a
threshold toxicity concentration if this association exists.