Olanzapine for Acute Headaches

• Status: Completed
• Trial end date: 2018-05-20
• Target enrollment: 0
• Participant gender: All

Summary

This trial is a prospective, randomized, feasibility trial with the primary aim of comparing how well oral rapidly dissolving olanzapine controls primary headache pain when compared to the current treatment strategies used in emergency departments which often require intravenous or intramuscular medications.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: HealthPartners Institute
• Treatments: Olanzapine

Criteria

Inclusion Criteria:

1. Adult patient between 18-65 years of age presenting to the emergency department with acute primary headache

2. Patient approved for inclusion by primary attending physician in the emergency department

Exclusion Criteria:

1. Age < 18 or > 65

2. Pregnancy

3. Known allergy to olanzapine

4. Known QT prolongation or underlying condition that places patient at risk for QT prolongation

5. Inability to give written consent (intoxication, altered mental status)

6. Headache of organic origin (trauma, infection, previous recent head or neck surgery)

7. Patient already prescribed daily olanzapine on an outpatient basis

8. Patient has been administered olanzapine within the past 24 hours

9. Language barrier