Oligopin Supplementation and Bone Turnover Markers and Antioxidant Changes in Postmenopausal Osteopenic Women
Status:
Completed
Trial end date:
2019-03-01
Target enrollment:
Participant gender:
Summary
Osteoporosis fractures impose a significant economic burden on the health system. There is
evidence that osteoporosis has a high prevalence in Iran (4.8% for men and 7.7% for women),
and the frequency of osteopenia is 36.8% for men and 39.3% for women in Iran Accordingly, the
prevention of osteopenia progression towards osteoporosis has been considered as an important
issue in medicine. Bone is a dynamic tissue that is constantly being remodeled thus the
equilibrium between bone formation and resorption done by simultaneously regulating
osteoclasts and osteoblasts is important. Imbalance between bone deposition and resorption
contributes to reducing bone mineral density and hence increasing the risk of osteoporosis
Recently, new therapies have been focused on use of medicinal herbs, especially
phytochemicals. Among phytochemicals, phytonutrients, and especially polyphenols, can act
both on osteoblast and on osteoclast.
Pine bark extract (oligopin) is a rich source of polyphenols that exerts strong antioxidant
and anti-inflammatory activities. It has also beneficial effects on bone turnover based on in
vitro studies and animal models. Investigators aimed to investigate the effects of oligopin
on bone turnover markers and plasma and peripheral mononuclear cells oxidative stress in
postmenopausal women with osteopenia in a double-blind randomized clinical trial.
Participants are forty four women with osteopenia divided into two groups randomly (22,
having oligopin, 150 mg, once daily, for 12 weeks). The 2nd group (22 women with osteopenia)
receives the same amount of the placebo. At the first and the end of the study, blood sample
are taken to measure in order to peripheral blood mononuclear cells isolation and plasma
separation. The levels of bone alkaline phosphatase and carboxy terminal collagen type I in
plasma oxidative stress markers such as total anti-oxidant capacity, malondialdehyde, and
protein carbonyl were evaluated. Furthermore, oxidative stress will be evaluated in
peripheral blood mononuclear cells by measurement of expression and activity of magnesium
superoxide dismutase,catalase and Nuclear factor (erythroid-derived 2)-like 2.