Omega 3 Action on Cardiovascular Risk Factors in Patients Treated With Statins
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Recent evidences showed beneficial effects of omega-3 fatty acids on cardiovascular morbidity
and mortality.
Regular Omega-3 fatty acid consumption reduces cardiovascular mortality, ischemic heart
disease and stroke mortality. There is probably no single mechanism of action that explains
this beneficial effect; but possible mechanisms include reduce susceptibility of the heart to
ventricular arrhythmia, antithrombogenic effect, reduce triglyceride level, promotion of
nitric oxide-induced endothelial relaxation, and retard growth of atherosclerotic plaque.
The combination of satins and omega3 was proved to be better the any of the drugs alone in
several studies.
The purpose of the study is to investigate several possible mechanisms that may explain the
add on beneficial effect of omega-3 in hypercholesterolemic patients already treated with
satins.