Omega-3 Fatty Acids and Insulin Sensitivity

• Status: Completed
• Trial end date: 2015-06-08
• Target enrollment: 0
• Participant gender: All

Summary

This study is being done to understand the effects of dietary omega-3 fats on insulin sensitivity in adult men and women.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic
• Collaborators: Building Interdisciplinary Research Careers in Women's Health; National Center for Advancing Translational Science (NCATS); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Criteria

Inclusion criteria:

1. Age 18-65 years

2. Insulin resistant (Homeostasis Model Assessment (HOMA) Insulin Resistance (IR) ≥2.6)

Exclusion criteria:

1. Current use of omega-3 nutritional supplements

2. Fasting plasma glucose ≥126 mg/dL

3. Active coronary artery disease

4. Participation in structured exercise (>2 times per week for 30 minutes or longer)

5. Smoking

6. Medications known to affect muscle metabolism (e.g., beta blockers, corticosteroids, tricyclic-antidepressants, benzodiazepines, opiates, barbiturates, anticoagulants)

7. Renal failure (serum creatinine > 1.5mg/dl)

8. Chronic active liver disease (AST>144 IU/L and alanine transaminase (ALT)>165 IU/L)

9. Anti-coagulant therapy (warfarin/heparin)

10. International normalized ratio (INR) >3

11. Use of systemic glucocorticoids

12. Chronic use of NSAIDS or aspirin

13. Pregnancy or breastfeeding

14. Alcohol consumption greater than 2 glasses/day

15. Hypothyroidism

16. Fish or shellfish allergy