Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a large multi-center study to examine whether peri-operative intake of n-3 polyunsaturated fatty acids (PUFA) will reduce the occurrence of post-operative atrial fibrillation or flutter (AF) in patients undergoing cardiac surgery (CS).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborator: The OPERA Investigators

Criteria

Inclusion Criteria:

• Age 18 years or over

• Scheduled for CS on the following day or later, including coronary artery bypass, valve surgery, any other open cardiac surgery (i.e., that includes opening of the pericardium), or any combination.

• Sinus rhythm on current ECG (sinus bradycardia, sinus tachycardia, and ectopy are acceptable).

Exclusion Criteria:

• Regular use (3 or more days/week) of fish oil within the past 4 weeks.

• Known allergy or intolerance to fish oil or corn oil.

• Currently pregnant.

• Unable to provide informed written consent.

• Current or planned cardiac transplant or LVAD