Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia
Status:
Recruiting
Trial end date:
2022-10-28
Target enrollment:
Participant gender:
Summary
Investigators have previously found that sperm quality was not related to obesity indicators,
such as body mass index (bmi), waist circumference, waist-hip ratio, girth ratio and serum
lipid, but seminal plasma lipids could notably affect the sperm concentration, sperm
progressive ratio(PR), sperm DNA fragmentation index (DFI). These results indicates that
abnormal lipid metabolism in the male reproductive system may affect male fertility.
It seems that the sperm fatty acid spectrum is associated with n-3 polyunsaturated fatty
acids (PUFA) in dietary. Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) are the
most common n-3 PUFA. Only plasma DHA/EPA may reflect the quantity of DHA/EPA in adults. Most
research indicate that n-3 PUFA is the main polyunsaturated fatty acid in human sperm.
It is well known that diets have great influence on the gut microbiota composition. Many
researches have delineated the cause and effect relationship between disturbed gut microbes
and diseases, such as irritable bowel syndrome, obesity, diabetes. The disturbed gut
microbiota ecosystem may also lead to the intestinal mucosal permeability increasing, which
may result in endotoxemia and a series of metabolic syndrome. N-3 polyunsaturated fatty acids
may play an important role in regulating metabolism and physiological functions in the body.
A clinical research found that both total n-3 PUFA and DHA serum levels were significantly
correlated with microbiome alpha diversity. Therefore, investigators may try to figure out
the influence of n-3 PUFA supplement on gut microbiota composition and whether the gut
microbiota have influence on sperm parameters. So investigators apply for your permission to
collected the fecal samples from the participants, which will be a meaningful work.