On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication

• Status: Unknown status
• Trial end date: 2005-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate several aspects of chronic use of acid suppressing medication: dependence on maintenance therapy, the possibilities for on-demand use, and predictors (patient characteristics) for daily need, for on-demand use and for termination of chronic use.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: UMC Utrecht
• Collaborator: Takeda
• Treatments: Pantoprazole

Criteria

Inclusion Criteria:

• male and female (non-pregnant, non-lactating)out-patients between 18-75

• chronic users of acid suppressive therapy for at least 180 days over the last year

Exclusion Criteria:

• stage 3, 4 oesophagitis, Barrett's oesophagus, acute peptic ulcer

• gastric hypersecretory condition, predominantly IBS symptoms, previous gastric/oesophageal surgery, pyloric stenosis

• severe, unstable comorbidities

• alarm symptoms

• malignancies in the past 5 years

• use of NSAID, systemic glucocorticoids, Cox-2 inhibitors, acetylsalicylic acid more than 150 mg daily, drugs with pH-dependent absorption, anticholinergics