On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.

• Status: Completed
• Trial end date: 2019-12-08
• Target enrollment: 0
• Participant gender: All

Summary

On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kaohsiung Veterans General Hospital.
• Treatments: Esomeprazole

Criteria

Inclusion Criteria:

• patients between the ages of 20 and 80 years

• having symptoms of acid regurgitation, heart burn, or feeling of acidity in the stomach

• having Barrett's Esophagus proven by histology confirmation

• length of esophageal metaplastic mucosa equal to or longer than 1 centimeter

Exclusion Criteria:

• pregnancy,

• coexistence of serious concomitant illness (for example, decompensated liver cirrhosis and uremia)

• previous gastric surgery,

• allergic to esomeprazole,

• presence of dysplastic esophageal mucosa

• equivocal endoscopic diagnosis of Barrett's esophagus