The brow lift is a surgical procedure that has been practiced for several decades. A typical
indication is brow ptosis, which can be secondary to involutional changes or facial nerve
palsies. Several techniques have been described, including direct, mid-forehead, coronal, and
endoscopic approaches. Of these options, the direct brow lift allows for predictable
post-operative brow contour and excellent control over the degree of lift achieved. As with
any surgical procedure, with direct brow lift comes known undesirable post-operative
outcomes, the most common of which is forehead paresthesia from supraorbital nerve damage.
Other complications include alopecia and brow asymmetry. However, one of the main critiques
of direct brow lift remains the poor cosmesis that can result from scarring just above the
brow. A study conducted by Cho et al. concluded that of the main surgical techniques
currently employed for treatment of brow ptosis, direct brow lifts held the highest rates of
visible scarring.
Scarring can significantly impair an individuals' quality of life. This is particularly true
of facial scarring, which is often difficult to conceal. Much research has been conducted in
the area of treating postoperative, traumatic, and burn-related scarring. Cadet et al
completed a randomized controlled trial using topical silicone gel for direct brow
lift-related scarring, given the known benefit of silicone gel sheeting for the same, but did
not find a significant difference between treatment and control groups. Some effective
techniques described in the literature to date include long-pulsed non-ablative Nd:YAG laser,
as well as intralesional steroid injection. On the rise are studies looking into the use of
botulinum toxin A for treatment of unfavourable scarring and improved facial cosmesis.
Botulinum toxin is a neuromodulatory agent that has garnered usage in a variety of
therapeutic and cosmetic settings. More recently, injection of botulinum toxin as a means to
reduce scarring and improve outcomes in wound healing has been investigated. Several studies,
including two large metaanalyses, have shown this to be an effective method of treatment.
Proposed mechanisms include increased apoptosis and suppressed proliferation of fibroblasts
treated with botulinum toxin, modulated via the PTEN/PI3K/Akt pathway. Park et al added to
the in vitro literature by demonstrating that fibroblasts treated with botulinum toxin A
produced fewer extracellular matrix proteins and pro-fibrotic factors compared to untreated
cells. Another underlying mechanism that results in suboptimal wound healing is the constant
contraction and relaxation of facial muscles, causing repetitive microtrauma that ultimately
increases inflammation and impairs wound healing. It therefore stands to reason that by
temporarily paralyzing local musculature during the post-operative period, collagen
maturation can take place uninterrupted by excessive tensile forces.
Despite scarring being a widely known and undesirable complication of direct brow lift
surgery, there have been no studies to date examining the use of onabotulinum toxin injection
to reduce said scarring and improve outcomes. With this double masked, prospective,
randomized controlled trial, the investigators aim to determine whether injection of
onabotulinum toxin immediately following direct brow lift surgery can improve scores on
validated patient and observer scar scales.
Phase:
N/A
Details
Lead Sponsor:
Nova Scotia Health Authority
Collaborator:
Dalhousie Ophthalmology and Visual Sciences Research Group